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  • ICAR and TNAU E-Course Summarized

    Summarized Notes
  • The milk obtained from the transgenic cow ‘Rosie’ was

    Question: The milk obtained from the transgenic cow 'Rosie' was

    Options:

    More white in colour
    Rich in alpha-lactalbumin protein
    Nutritionally enriched
    Both 2 and 3

    🗝️ Key Points
    → The first transgenic cow was called Rosie and was produced in 1997.
    → It was genetically engineered to produce human protein-enriched milk.
    → This milk contained 2.4gms of human α-lactalbumin per litre of milk.
    → Normal cow milk does not contain this protein.
    → Thus, the milk from the transgenic cow was nutritionally more balanced for human babies than natural cow milk.

    📌 Additional Information
    → Transgenic animals refer to those that have had their genomes modified to possess and express a foreign gene.

    🔬 Reasons for Production of Transgenic Animals
    → Study of Physiology & Development
    → Study of how genes and their regulation affect the physiological functioning of the body.
    → Complex growth factors like insulin can be studied.
    → Study of Diseases
    → Transgenic animals serve as model organisms for studying human diseases.
    → They help in understanding the disease development process from genes.
    → They are also used for investigating new treatment methods.
    → Transgenic models exist for diseases like cancer, cystic fibrosis, rheumatoid arthritis, and Alzheimer's.
    → Biological Products
    → Many biological products essential for formulating medicines are often expensive.
    → These products can be obtained easily from transgenic animals.
    → This can be achieved by introducing the gene responsible for the desired product into a suitable organism.
    → Example: Alpha-1 antitrypsin is a human protein required for emphysema treatment.
    → Vaccine Safety
    → Transgenic mice can be used to test the safety of vaccines before use for humans.
    → Toxicity Testing
    → Transgenic animals can be made more sensitive to certain chemicals or drugs.
    → These animals are exposed to toxic substances, and their effects are then studied.

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