Question: In RNA, nitrogen bases are the same as in DNA except: (JFR Plant Science 2018)
Options:
Uracil instead of Thymine
Cytosine instead of Thymine
Adenine instead of Guanine
Thymine instead of Adenine
-RNA uses Uracil (U) as a nitrogenous base instead of Thymine (T) found in DNA. The other bases—Adenine (A), Guanine (G), and Cytosine (C)—are the same in both DNA and RNA.
-Nitrogenous Bases: These are essential building blocks that form the basic framework of nucleic acids, such as DNA and RNA.
-In DNA, the four nitrogenous bases are: Adenine (A), Thymine (T), Guanine (G), and Cytosine (C). These bases pair up to form base pairs: A pairs with T, and G pairs with C.
-In RNA, Thymine is replaced by Uracil (U). So, Adenine (A) pairs with Uracil (U) in RNA, unlike in DNA where it pairs with Thymine (T).
✏Reason for the Difference:
-DNA's role is primarily for long-term storage of genetic information, which requires stability. Thymine is chemically more stable and less likely to mutate.
-RNA, unlike DNA, is usually single-stranded and plays a role in transmitting genetic information from DNA to the ribosome for protein synthesis. Uracil is energetically less expensive to produce than Thymine, which likely explains the substitution in RNA.
-Thymine contains a methyl group (-CH3), a slight difference that helps in the identification and protection of DNA in the cellular environment.