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  • ICAR and TNAU E-Course Summarized

    Summarized Notes
  • When a pyrimidine is substituted by a purine and vice versa, this type of mutation is known as

    Question: When a pyrimidine is substituted by a purine and vice versa, this type of mutation is known as

    Options:

    Transition
    Transversion
    Non-sense mutation
    Miss-sense mutation

    ✅ Explanation:
    In DNA, there are two types of nitrogenous bases: purines (adenine and guanine) and pyrimidines (cytosine, thymine, and uracil in RNA).
    -A transition mutation occurs when a purine is replaced by another purine, or a pyrimidine is replaced by another pyrimidine.
    -A transversion mutation occurs when a purine is replaced by a pyrimidine, or vice versa.  

    📌 Other Options Explanations:
    -(a) Transition: While a type of point mutation, it involves the substitution between the same category of bases (purine-purine or pyrimidine-pyrimidine), not across categories.
    -(c) Non sense mutation: This type of mutation results in a premature stop codon, leading to a truncated, non-functional protein.
    -(d) Miss sense mutation: This type of mutation results in a change in one amino acid in the protein sequence.

    🔑Key Points:
    -Transversional mutants: When in the DNA molecules, one purine-pyrimidine base pair is replaced by another purine-pyrimidine base pair, it is called a transversional mutation. This type of mutation involves a change from a purine to a pyrimidine or from a pyrimidine to a purine. For example, an adenine (A) being replaced by a thymine (T) or a guanine (G) being replaced by a cytosine (C).
    -Transitional mutants: This type of mutation involves a purine being replaced by another purine or a pyrimidine being replaced by another pyrimidine. For example, adenine (A) being replaced by guanine (G) or cytosine (C) being replaced by thymine (T). 
    -Insertion mutants: This type of mutation involves the addition of one or more nucleotide base pairs into the DNA sequence. This can cause a shift in the reading frame of the genetic code, potentially leading to significant changes in the protein produced. 
    -Deletion mutants: This type of mutation involves the removal of one or more nucleotide base pairs from the DNA sequence. Like insertions, deletions can also cause a frameshift, leading to potentially harmful effects. 

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