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  • ICAR and TNAU E-Course Summarized

    Summarized Notes
  • A cruciform structure of chromosomes during meiosis is a characteristic feature of:

    Question: A cruciform structure of chromosomes during meiosis is a characteristic feature of:

    Options:

    Translocation
    Inversion
    Deletion
    Duplication

    🔑Key Points:
    -A chromosomal abnormality, or chromosomal aberration refers to any disorder that is characterized by a morphological or numerical change in single or multiple chromosomes, that affects autosomes, sex chromosomes, or both.
    Types of chromosomal aberration – 

    ✏️Deletion:
    -Deletion refers to the loss of a segment of a chromosome.
    -It can be of two types: terminal and interstitial.
    -Terminal deletion involves a single break while interstitial deletion rinvovled two breaks. 
    -Generally deletion is lethal because it causes genetic imbalance in diploid organisms. 

    ✏️Duplication:
    -Duplication refers to occurence of a segment of DNA of a chromsomes in two or more copies per genome. In this case, the duplicated segments can be located next to one another or they can be dispersed on the same chromosome.  
    -It is produced as the result of abnormal events during recombination. 
    -It can be of two types – direct and inverted. 
    -In direct duplication, the duplicated segments keeps the same orientation with respect to the centromere.
    -In inverted duplication, the duplicated segments takes the opposite orientation.
    -Inversion: 
    -Inversion is a type of chromosomal mutation that results in a change in the nucleotide sequence of a gene or a chromosome.
    -It starts with two double-stranded breaks within a segment of chromosomes.Then entire fragment is rotated end-to-end between the fracture lines, and the re-fusion of the fragment. 
    -This causes a change in the order of the genes in the section that is inverted. 
    -Chromosomal inversion is of two types – 
    -Paracentric inversion: It does not involve the centromere and only one arm of the chromosome has two breaks.
    -Pericentric inversion:  It involves a centromere with each arm having one double-stranded break.
    -Translocation: 
    -Translocation refers to exchange of chromosomal segments between two non-homologous chromosomes. 
    -It can be of two types: reciprocal and non-reciprocal.
    -Non-reciprocal translocation involves the transfer of segment in one direction from one chromosome to another. 
    -Reciprocal translocation involves exchange of the segments of chromosomes between non-homologous chromosomes, this results in the generation of two translocated chromosomes simultaneously. 

    ✅ Explanation:
    -Translocation typically affects the product of meiosis. 
    -In the strains that are homozygous for a reciprocal translocation, meiosis occurs normally, all chromosomes can pair and crossing over does not leads to the production of abnormal chromatids. 
    -In the strains that are heterozygous for a reciprocal translocation, then all the homologous chromosomes pairs in best way possible this leas to generation of cross-like (cruciform) configuration in meiotic prophase I. 
    -So, cruciform structure is seen in the event of reciprocal translocation that takes place during meiosis process.

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