DNA is a polymer of nucleotides that are linked to each other by a 3’-5’ phosphodiester bon D. To prevent the polymerization of nucleotides, which of the following modifications would you choose?

📌 Concept:
-The condensation polymerization makes DNA (deoxyribonucleic acid) of repeating units (monomers) called nucleotides.
-In a polynucleotide chain, consecutive nucleotides are linked to one another through phosphodiester bonds formed between the phosphate of one nucleotide and the sugar of the next nucleotide.
-It helps in the formation of dinucleotides or polynucleotides.
-The phosphodiester bond links the 3' carbon of one sugar is bonded to the 5' phosphate of the adjacent sugar.

✅ Explanation:
Option 1) Replace purine with pyrimidines
-Replacement of purine and pyrimidines will not prevent the polymerization of nucleotides.
Option 2) Remove/Replace 3' OH group in deoxy ribose
-Polymerization of DNA occurs when the 3’OH group binds to the deoxyribose.
-If the 3’ OH group is removed/replaced in deoxyribose polymerization will be prevented
Option 3) Remove/Replace 2' OH group with some other group in deoxy ribose.